Renal mitochondrial restoration by gymnemic acid in gentamicin-mediated experimental nephrotoxicity: evidence from serum, kidney and histopathological alterations

Background: Nephrotoxicity refers to the toxigenic impact of compounds and medications on kidney function. There are a variety drug formulations, some medicines that may affect renal function in multiple ways via nephrotoxins production. Nephrotoxins substances harmful kidneys. Purpose: This investigation examines renoprotective effect gymnemic acid (GA) Wistar rats gentamicin-induced nephrotoxicity by analyzing serum, kidney, histopathological markers. Study-design/methods: The current study investigated protective GA at doses 20, 40, 60 mg/kg against rats. Vitamin E was administered compare antioxidant capacity efficacy GA. In addition treatment groups, 100 gentamicin intraperitoneal for 14 days. At end protocol, homogenate, blood, serum were evaluated biochemically. Serum creatinine, blood urea, glomerular filtration rate (GFR), mitochondrial dysfunctions, inflammatory cytokines, oxidative stress examined assess nephrotoxicity. addition, above-mentioned nephrotoxic markers further confirmed histological analysis. Results: establishes correlation between antibiotic use, especifically aminoglycosides acute failure. research demonstrates effects aminoglycosides, inducing ETC-complex dysfunction, tissue inflammation experimental GA’s properties restored markers, reducing injury. Histopathological analysis revealed significant reduction injury with treatment. Additionally, demonstrated greater than restoring potential enzymes. Conclusion: Consequently, our findings imply long-term use be suitable therapeutic strategy aminoglycoside toxicity. suggests treating failure, meriting using advanced techniques.